![]() ![]() If the sample results come back as pre-receptive or post-receptive, doctors will then adjust the scheduled embryo transfer to account for these changes The embryo is less likely to implant at this time. The lining has already reached the stage for optimal embryo implantation but is no longer in that stage. The lining is ready to receive the embryo, which is most likely to implant. The lining is not yet ready to receive an embryo, and implantation is less likely to occur. The sample will be sent to a lab where molecular analysis is completed to determine the best time to attempt embryo implantation in a future IVF cycle. Some women experience cramping or light bleeding during or after the procedure. The doctor will use the pipelle to “scratch” the uterine lining and obtain a small amount of tissue for testing. During the biopsy a small instrument called a pipelle is inserted through the vagina. The biopsy is a straightforward, outpatient procedure with minimal discomfort. An endometrial biopsy is performed on the standard embryo transfer day (in lieu of an actual embryo transfer), when the window of implantation is expected to occur. The woman will begin taking sequential hormones, including estrogen and progesterone in advance of the procedure, as she would in preparation for a frozen embryo transfer. The endometrial receptivity array procedure will typically begin 1-1 ½ months prior to a frozen embryo transfer. ![]() However, it’s always important for women to discuss their personal situation with their doctor. The ERA endometrial biopsy is not part of a female fertility evaluation and is not typically recommended for first-time IVF patients. Maximize Your Chances of Pregnancy Who should consider an ERA biopsy?ĮRA biopsy may be an option for women already undergoing infertility treatment and is typically recommended for women who have had previous IVF cycle failures or have experienced miscarriage or recurrent pregnancy loss. ERA is also a diagnostic tool used to determine if a woman’s uterine lining is a contributing factor in recurrent IVF implantation failure and recurrent pregnancy loss. During each monthly cycle, a woman’s uterine lining is most receptive for a period of 4-5 days known as the “window of implantation.”ĮRA biopsies can be used to identify when a woman’s uterine lining is in that window of implantation. In order for implantation to occur, the uterine lining must be capable of receiving and nurturing an embryo. Second, the resulting embryo, which will be in the blastocyst stage of development, implants into the uterine lining, where it will then develop. The egg must be fertilized by the man’s sperm that travels to the fallopian tubes where it meets the egg for fertilization. Once released the egg is only viable for 12-24 hours. Conception is a complex biological process with a significant number of variables.įirst, the woman’s ovaries need to release an egg. In order to understand ERA testing, it can be helpful to review how the female reproductive system works. Zeigler’s Podcast on ERA Biopsy How can an ERA biopsy help with embryo implantation? The endometrial receptivity assay (ERA) attempts to analyze the endometrial lining at the molecular level, and elicits further information about this window of implantation by evaluating 248 genes. It is thought that some patients may have alterations of their “window of implantation” that may decrease their implantation rate and pregnancy success using traditional ultrasound and hormone assessment. Although ultrasound is an established entity, there is a subset of patients who have an appropriate endometrial lining and transfer of morphologically high-quality embryos, who fail to successfully conceive and have a live birth following an IVF cycle. Physicians use ultrasound technology to examine the thickness and pattern of the endometrial lining in preparation for embryo implantation during an IVF cycle. The results of an ERA biopsy are used to predict the ideal implantation window for the above patients.ERA biopsy may be considered for women who have undergone IVF cycles in which implantation failed or for women who have experienced multiple miscarriages or recurrent pregnancy loss.Problems with the endometrial lining are one of the causes for infertility in women with recurrent pregnancy loss or multiple failed in vitro fertilization (IVF) transfers.ERA endometrial biopsy is a relatively new procedure, which involves biopsying a small sample of the endometrium, or lining of the uterus, for molecular analysis.Endometrial receptivity array (ERA) is a diagnostic procedure that may help determine whether the endometrial cavity is ready for embryo implantation.Endometrial Receptivity Array (ERA) Endometrial Biopsy Endometrial receptivity array at a glance ![]()
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